Immune Plasticity and Molecular Ecoepidemiology Lab

Papers published

  • Peñín, I., Figueroa-Cabañas, M.E., Guerrero-de la Rosa, F., Soto-García, L.A., Álvarez-Martínez, R., Flores-Morán, A., Acevedo-Whitehouse, K. (2019). Transcriptional Profiles of California Sea Lion Peripheral NK and CD+8 T Cells Reflect Ecological Regionalization and Infection by Oncogenic Viruses. Frontiers in Immunology 10:413. doi: 10.3389/fimmu.2019.00413

  • Morales-Guerrero, B.,  Gendron, D., Martinez-Levasseur, L.M., Acevedo-Whitehouse, K. (2019). Blue whale, Balaenoptera musculus, skin contains eumelanin and pheomelanin. Aquatic Mammals 45, 88-98. doi: 10.1578/AM.45.1.2019.88.

  • Stoffel, M.A., Humble, E., Acevedo-Whitehouse, K., Chilvers, B.L., Dickerson, B., Galimberti F., Gemmell, N., Goldsworthy, S.D., Nichols, H.J, Krüger, O., Negro, S., Osborne, A., Paijmans, A.J., Pastor, T., Robertson, B.C. , Sanvito, S., Schultz, J., Shafer, A.B.A., Wolf, J.B.W., & Hoffman, J.I. (2018) Recent demographic histories and genetic diversity across pinnipeds are shaped by anthropogenic interactions and mediated by ecology and life-history. Nature Communications 9: 9:4836. doi: 10.1038/s41467-018-06695-z

  • Peñin, I., Levin, M., Acevedo-Whitehouse, K., Jasperse, L., Gebhard, E., Gulland, F.M.D., De Guise, S. (2018) Effects of polychlorinated biphenyls (PCB) on California sea lion (Zalophus californianus) lymphocyte functions upon in vivo exposure. Environmental Research 167: 708-717. doi: 10.1016/j.envres.2018.08.028

  • Acevedo-Whitehouse, K., Cole, K.J., Philliips, D.H., Jepson, P.D., Deaville, R., Arlt, V.M. (2018) Hepatic DNA damage in Harbour Porpoises (Phocoena phocoena) Stranded along the English and Welsh Coastlines. Environmental and Molecular Mutagenesis 59:613-624. doi: 10.1002/em.22205

  • Domínguez-Sánchez, C.A., Acevedo-Whitehouse, K., Gendron, D.. (2018) Effect of Drone-based blow sampling on blue whale (Balaenoptera musculus) behaviour. Marine Mammal Science 34: 841-850. doi: 10.1111/mms.12482

  • Acevedo-Whitehouse, K., Gulland, F.M.D., Bowen, L. (2018) MHC class II DRB diversity predicts antigen recognition and is associated with disease severity in California sea lions naturally infected with Leptospira interrogans. Infection Genetics and Evolution 57: 158–165. https://doi.org/10.1016/j.meegid.2017.11.023

  • Espinosa-de Aquino, W., Bailey, M., Acevedo-Whitehouse, K. (2017) Changes in mucosal and serum immunoglobulin levels of California sea lions during early development. Developmental and Comparative Immunology 77: 166e173. http://dx.doi.org/10.1016/j.dci.2017.08.006

  • Flores-Morán, A., Banuet-Martínez, M., Elorriaga-Verplancken, F.R., García-Ortuño, L.E., Sandoval-Sierra, J., Acevedo-Whitehouse, K. (2017). Atypical red blood cells are prevalent in California sea lion pups born during anomalous sea surface temperature events. Physiological and Biochemical Zoology 90: 564-574. doi: 10.1086/692919

  • Banuet-Martinez, M., Espinosa-de Aquino, W., Elorriaga-Verplanken, F.R., Flores-Morán, A., García, O.P., Camacho, M., Acevedo-Whitehouse, K. (2017). Climatic anomaly affects the immune competence of California sea lion pups. PLoS ONE 12(6):e0179359. doi: 10.1371/journal.pone.0179359. eCollection 2017.

  • Elorrigaga-Verplancken, F.R., Acevedo-Whitehouse, K, (2017). Probable intersexual altruistic behavior in California sea lions. Aquatic Mammals 43: 208-212. doi: https://doi.org/10.1578/AM.43.2.2017.208

  • Espinosa-de Aquino, W., Olvera-Ramírez, A., Arellano-Carbajal, F., Lanz-Mendoza, H., Villagrán-Herrera, E., Acevedo-Whitehouse, K. (2017). Protein and RNA extraction from mucosal swabs: a minimally invasive source of ecological data for studies of natural populations Methods in Ecology and Evolution 8:370-378. doi: 10.1111/2041-210X.12680

  • Morales-Guerrero, B., Barragán-Vargas, C., Silva-Rosales, G. R., Ortega-Ortiz, C. D., Gendron, D., Martinez-Levasseur, L. M., Acevedo-Whitehouse K (2017). Melanin granules melanophages and a fully-melanized epidermis are common traits of odontocete and mysticete cetaceans. Veterinary Dermatology 28:213-218. doi: 10.1111/vde.12392

  • Elorriaga-Verplancken, F. R., Sierra-Rodriguez, G. E., Rosales-Nanduca, Acevedo-Whitehouse, K., Sandoval-Sierra, J. (2016). Impact of the 2015 El Niño-Southern Oscillation on the abundance and foraging habits of Guadalupe fur seals and California sea lions from the San Benito Archipelago, Mexico. Plos One 1:16. doi:10.1371/journal.pone.0155034

  • Montano-Frías, J. E., Álvarez-Martinez, R. C., Flores-Morán, A. E., Acevedo-Whitehouse, K. (2016). MHC class II transcription is associated with inflammatory responses in a wild marine mammal. Infection Genetics and Evolution 42: 77-82. doi: 10.1016/j.meegid.2016.04.022

  • Barragán-Vargas, C., Montano-Frías, J. E., Silva-Rosales, G. R., Godínez-Reyes, C. R., Acevedo-Whitehouse, K. (2016) Transformation of the genital epithelial tract occurs early during California sea lion development. Royal Society Open Science 3: 15041DOI: 10.1098/rsos.150419

  • Brock, P. M., Goodman, S. J., Hall, A. J., Cruz. M., Acevedo-Whitehouse, K. (2015) Context dependent associations between heterozygosity andimmune variation in a wild carnivore. BMC Evolutionary Biology 15: 242.  doi:10.1186/s12862-015-0519-6

  • Vera-Massieu, C. Brock P. M., Godinez-Reyes, C. R., Acevedo-Whitehouse, K. (2015) Activation of an inflammatory response is context-dependent during early development of the California sea lion. Royal Society Open Science 2:150108. http://dx.doi.org/10.1098/rsos.150108

  • Browning, H. M*., Acevedo-Whitehouse, K*., Gulland, F. M. D., Hall, A. J., Finlayson, J, Dagleish, M. P, Billington, K J, Colegrov,e K, Hammond, JA. (2014) Evidence for a genetic basis of urogenital cancer in the wild California sea lion. Proceedings of the Royal Society of London B. 281. DOI: 10.1098/rspb.2014.0240

  • Martinez-Levasseur, L. M., Birch-Machin, M. A., Bowman, A., Gendron, D., Weatherhead, E., Knell, R. J., Acevedo-Whitehouse, K. (2013). Whales Use Distinct Strategies to Counteract Solar Ultraviolet Radiation. Scientific Reports 3:2386. DOI: 10.1038/srep02386

  • Martinez-Levasseur, L. M., Gendron, D., Knell, R. J., Acevedo-Whitehouse, K. (2013) Control and target gene selection for studies on UV-induced genotoxicity in whales. BMC Research Notes 6:264 doi: 10.1186/1756-0500-6-264

  • Brock, P. M., Hall, A. J., Goodman, S. J., Cruz, M., Acevedo-Whitehouse, K. (2013) Immune Activity, Body Condition and Human-Associated Environmental Impacts in a Wild Marine Mammal. PLoS ONE 8(6). e67132. doi:10.1371/journal.pone.0067132

  • Bowman, A., Martinez-Levasseur, L. M., Acevedo-Whitehouse, K., Gendron, D., Birch-Machin, M. A. (2013) The simultaneous detection of mitochondrial DNA damage from sun-exposed skin of three whale species and its association with UV-induced microscopic lesions and apoptosis. Mitochondrion pii: S1567-7249(13)00066-4. doi: 10.1016/j.mito.2013.04.003

  • Jepson, P.D., Deaville, R., Acevedo-Whitehouse, K., Barnett, J., Brownlow, A., Brownell Jr, R. L., Clare, F. C., Davison, N., Law, R.J., Loveridge, J, Macgregor S.K., Morris, S., Murphy, S.,  Penrose, S., Perkins, M.W., Pinn, E., Seibel H., Siebert, U., Sierra E., Simpson, V., Tasker, M.L., Tregenza ,N.,  Cunningham, A.A., Fernández, A. (2013) What caused the UK’s largest common dolphin (Delphinus delphis) mass stranding event? PLoS ONE 8(4): e60953. doi:10.1371/journal.pone.0060953

  • Pettorelli, N., Evans, D: M., Garner, T. W. J., Katzner, T., Gompper, M. E.,  Altwegg, R., Branch, T. A., Johnson, J. A., Acevedo-Whitehouse, K., DaVolls, L.,, Rantanen, E., Gordon, I. J. (2013) Addressing gender imbalances in Animal Conservation. Animal Conservation 16: 131-133 doi:10.1111/acv.12032

  • Brock, P., Hall, A., Goodman, S., Cruz, M., Acevedo-Whitehouse, K. (2013) Applying the tools of ecological immunology to conservation: a test case in the Galapagos sea lion. Animal Conservation 16(1): 19-31. doi:10.1111/j.1469-1795.2012.00567.x

  • Gordon, I. J., Acevedo-Whitehouse, K., Altwegg, R., Garner, T. W. J., Gompper, M. E., Katzner, T. E., Pettorelli, N., Redpath, S. (2012) What the ‘food security’ agenda means for animal conservation in terrestrial ecosystems. Animal Conservation 15(2): 115-116. doi:10.1111/j.1469-1795.2012.00541.x

  • Lima, N., Rogers, T., Acevedo-Whitehouse, K., Brown, M. V. (2012). Temporal stability and species specificity of bacteria associated with the bottlenose dolphin respiratory system. Environmental Microbiology Reports 1-8. doi:10.1111/j.1758-2229.2011.00306.x

  • Branch, T. A., Austin, J., Acevedo-Whitehouse, K., Gordon, I. J., Gompper, M. E., Katzner, T. E. & Pettorelli, N. (2011). Fisheries conservation and management: finding consensus in the midst of competing paradigms. Animal Conservation 14(6): 1-3.

  • Werner, R.., Forcada, J., Bertellotti, M., Crespo, E. A., Dans, S., Degrati, Y., Fazio, A., Grandi, M. F., Loizaga, R., Coscarello, M., Bossio, L., Carribero, A., Geremias, N., Lindner, M. S., Romina, E., Rosas, C. L., Sironi, M., Taboada, D., Guiland, F., Reeves, R. R., Groch, K., Krapovickas, S., Conchillo, D., Chirife, A., Rowntree, V. l , Thomas, P. O., Brownell, R. L., Rowles, T., Harris, G., Mcaloose, D., Uhart, M., Vila, A., Rosenbaum, H., Moore, M., Jepson, P., Acevedo-Whitehouse, K. (2011) Report of the Southern Right Whale die-off workshop. Journal of Cetacean Research and Management 12, SUPPL: 367-398.

  • Donnelly, R. E., Katzner, T., Gordon I. J., Gompper, M. E. Redpath, S., Garner, T. W. J., Altwegg, R., Reed, D. H., Acevedo-Whitehouse, K., Pettorelli, N. (2011) Putting the eco back in ecotourism. Animal Conservation. 14, 325-327.

  • Martinez-Levasseur, L. M., Gendron, D., Knell, R. J., O’Toole, E. A., Singh, M., Acevedo-Whitehouse, K. (2011) Acute sun damage and photoprotective responses in whales. Proceedings of the Royal Society of London B 278: 1581-1586.

  • González-Hernández, M, Denoël, M, Duffus, A. J. L., Garner, T. W. J., Cunningham, A. A., Acevedo-Whitehouse, K. (2010) Dermocystid infection and associated skin lesions in free-living palmate newts (Lissotriton helveticus) from Southern France. Parasitology International. 59: 344-350.

  • Acevedo-Whitehouse, K., Rocha-Gosselin, A., Gendron, D. (2010) A novel non-invasive tool for disease surveillance of free ranging whales and its relevance to conservation programmes. Animal Conservation 13, 217-225.

  • Acevedo-Whitehouse, K., Duffus, L. J. A. (2009) Effects of environmental change on wildlife health. Philosophical Transactions Royal Society B 364: 3429-3438.

  • Estrada-Pena, A., Naranjo, V., Acevedo-Whitehouse, K., Mangold, A. J., Kocan, K. M., de la Fuente, J. (2009) Phylogeographic analysis reveals association of tick-borne pathogen, Anaplasma marginale, MSP1a sequences with ecological traits affecting tick vector performance. BMC Biology 7: 57.

  • Acevedo-Whitehouse, K., Petetti, L., Duignan, P., Castinel, A. (2009) Hookworm infection, anaemia and genetic variability of the New Zealand sea lion. Proceedings Royal Society B 276: 3523-3529.

  • Acevedo-Whitehouse, K. (2009) The importance of disease management programs for wildlife conservation. Animal Conservation. 12: 185-186.

  • Smith, K.F., Acevedo-Whitehouse, K., Pederson, A. (2009) The role of infectious diseases in biological conservation. Animal Conservation 12: 1-12.

  • Amos, W., Acevedo-Whitehouse, K. (2009) A new test for genotype – fitness associations reveals a single microsatellite allele that strongly predicts the nature of tuberculosis infections in wild boar. Molecular Ecology Resources 9:1102-1111.

  • Naranjo, V., Acevedo-Whitehouse, K., Vicente, J., Gortazar, C., de la Fuente, J. (2008) Influence of methylmalonyl-CoA mutase alleles on resistance to bovine tuberculosis in the European wild boar (Sus scrofa) . Animal Genetics 39: 316-320.

  • Acevedo-Whitehouse, K., Cunningham, A. (2006) Is MHC enough for understanding wildlife immunogenetics? Trends in Ecology and Evolution 21: 433-438.

  • Acevedo-Whitehouse, K., Spraker, T. R., Lyons, E., Melin, S. R., Gulland, F., DeLong, R. L., Amos, W. (2006) Contrasting Effects of Heterozygosity and Survival and Hookworm Resistance in California Sea Lion Pups. Molecular Ecology 15:1973-1982

  • Acevedo-Whitehouse, K., Vicente, J., Höfle, U., Fernández de Mera, I. G., Amos, W.  Gortazar, C. (2005) Genetic resistance to bovine tuberculosis in wild boars. Molecular Ecology 14:3209-3217.

  • Acevedo-Whitehouse, K., Gulland, F., Greig, D., Amos, W. (2003) Inbreeding: Disease susceptibility in California sea lions. Nature 422:35.

  • Acevedo-Whitehouse, K., de la Cueva, H., Gulland, F. M., Aurioles-Gamboa, D.,  Arellano-Carbajal, F., Suárez-Güemes, F. (2003) Evidence of Leptospira interrogans infection in California sea lion pups from the Gulf of California. Journal of Wildlife Diseases 39:145-151.

  • Acevedo-Whitehouse, K., Constantino-Casas, F., Aurioles-Gamboa, D., Rodríguez-Martínez, H. A., Godínez-Reyes, C. R. (1999) Hepatic carcinoma with spleen metastasis in a California sea lion from the Gulf of California. Journal of Wildlife Diseases 35: 565-568.

Book chapters

  • K. Acevedo-Whitehouse, L. Bowen. (2018). Genetics. In: CRC Handbook of Marine Mammal Medicine (Dierauf, L., Gulland, F.M.D.) CRC Press, New York. 1124 pp. ISBN 9781498796873

  • K. Acevedo-Whitehouse, L. Soto-García. (2017). Emerging Pathogens and Health Issues in the 21st Century: A Challenge for Tropical and Subtropical Pinnipeds. In: Tropical Pinnipeds. CRC Press. 325 pp. ISBN 9781498741392

  • L. M. Martínez-Levasseur, D. Gendron, .R .J. Knell, E. A. O’Toole, M. Singh, A. Bowman, M. Birch-Machin, K. Acevedo-Whitehouse (2013). Responses to acute sun exposure in large whales. McGraw Hill Yearbook of Science and Technology. McGraw Hill Education 459 pp.

  • J. Ewen, K. Acevedo-Whitehouse, M. Alley, C. Carraro, T. Sainsbury, K. Swinnerton and R. Woodroffe (2012). Chapter 9: Empirical consideration of parasites and health in reintroduction. En: Reintroduction biology: current issues for science and management. Wiley-Blackwell.